Events

Our first Speaker Guilherme Costa from acib GmbH, will present an innovative approach to the downstream processing of complex biotherapeutics. Downstream processing is a critical challenge in the manufacture of complex biotherapeutics, particularly vital vectors, and virus-like particles. While density-gradient ultracentrifugation offers high-resolution separation, traditional tube-based formats lack the scalability required for manufacturing. Continuous-flow ultracentrifugation addresses this by enabling continuous sample loading and particle capture within dynamic density gradients. This presentation will introduce how continuous-flow ultracentrifugation can be used for particle capture, discuss the key process parameters that influence its performance, and explore the challenges of translating the technology from research-scale to pilot- and manufacturing-scale systems.