drug development: hamster and book

Did you know that nowadays bacteria and mammalian cells, especially hamster cells, produce a wide range of drugs? And who tells them to do so? The answer is the four-letter code of DNA. Biotechnologists spend a lot of time to explore natural DNA sequences of different organisms for production. The Chinese Hamster is a mammalian system and suits well for cell factories because of its similarity to human cells. However, for a long time the knowledge about the hamster DNA sequence had many gaps that needed to be investigated.

Symbolic image of drugs

Co-author: Martin Walpot

In the development of drugs and pharmaceutical compounds, expensive tests are necessary, to know, which metabolic by-products and side-effects could emerge and to ensure that drugs are working effectively and in a safe manner. Human-like CYP450 enzymes, which mimic the same activities happening in the human body, are new, excellent biocatalytic tools to screen side effects outside the human body. They also enable the timely production of reasonable amounts of active pharmaceutical ingredients. Used as biocatalysts in industrial applications, new CYP450 enzymes, developed in the EU-project ROBOX, have the potential to speed up drug development, enhance pharmaceutical safety and to innovate chemical markets such as flavour-, fragrance or food industries.

targeting cancer - pink ribbon

The complex tumour structure makes the treatment of breast cancer a medical challenge. A promising, novel selenium-based breast cancer nanoparticle therapy, which is topic of the EU-project Neosetac, could change that: It has proved to boost the active agent delivery and assure it’s active only in the target tissue while also bringing the suggestion of reduced side effects. The project findings are expected to increase the efficiency of future chemotherapies and prevent recurrence of the cancer after complete remission.

In our previous article Insights into crowdfunding the concept of crowdfunding was explained while the following article focuses on investment. Crowdinvesting is not a miracle. However, there are a few myths due to misinformation about some basic principles and due to still changing legal provisions of this new financial instrument. Some of these myths are related to the expectations about the parties involved.  The following facts are supposed to dismantle the myths of crowdinvesting.

Enzyme im Alltag - die Enzos

Auf das Abenteuer Forschung haben sich im Rahmen des Projektes „Enzyme im Alltag“ neun Schulklassen aus Volksschulen, NMS und Gymnasien eingelassen. Gemeinsam mit Wissenschaftlerinnen und Wissenschaftlern vom acib und der TU Graz und den Firmenpartnern Bisy, Qualizyme und QPS erkundeten die Kinder und ihre Lehrkräfte innerhalb von 2 Jahren die enorme Vielfalt enzymatischer Abläufe und entdeckten sie im täglichen Leben.

sugar beets

Sugar is not only a widely used food ingredient but can also be used as possible starting point for high-added-value products. The European research consortium of CARBAFIN explores different ways to make use of sugar beet biomass: the sugar components glucose and fructose are starting points for the production of important ingredients for not only food/feed but also cosmetics. Besides, fructose can be further converted to a platform chemical, which is applied to the production of bioplastics, biofuels or biopolymers, as well as resins. In other words, CARBAFIN people sweeten our lives!

Capsaicin

Have you ever wondered, why it often takes many years until a new drug is available at your local pharmacy? One of the reasons is that the pharmaceutical industry wants to make sure that the drug is not only effective but also doesn’t produce toxic breakdown products that lead to undesireable side effects. Therefore, many time-consuming and not seldomly expensive tests are required to know precisely, which possible metabolic by-products could emerge. In a next step, the industry is producing such derivates to test them thoroughly for their side-effects, ensuring one goal: the patients health and wellbeing. 

red blood cells - Biosensors for blood grouping

Biosensors may soon facilitate the analysis of a patient’s entire red blood cell antigen repertoire. In the form of diagnostic test strips, they could make the analysis swift and location-independent. This could have enormous potential not only in medical diagnosis, but also for environmental analysis if extended to other analytes.

Insights into crowdfunding

Crowdfunding became known around 2005/06 in the creative industries. To cope with illegal downloads in the music industries, money was raised before publishing. However, the concept of crowdfunding is much older. In 1885 the Statute of Liberty would not have been completed without a newspaper-led campaign (by Joseph Pulitzer of the New York World) that attracted 160,000 donors.