Enzyme spielen die erste Geige, die Zelle ist ein Saal für das gesamte – perfekt eingespielte – Orchester und ForscherInnen wirken als Komponisten? Heraus kommen dabei nicht etwa Töne sonder Düfte! Unser musikalischer Denkansatz veranschaulicht die komplexen Produktionsprozesse in der Biotechnologie anhand eines Beispiels aus dem Aromastoff-Bereich.
Carbon dioxide (CO2) emission is a massive problem for our climate; this is well-known. We urgently need measures to prevent earth from the big collapse. Where do we find them? Biotechnology offers some interesting solutions.
While currently most production processes for biopharmaceuticals are assessed by laboriuos and time-consuming off-line analytics, a new process enables the monitoring of such processes in real-time. Sensors combined with mathematical models deliver information on the quality and quantity of the product, as well as on content and profile impurities. This allows an instant monitoring of processes, making processes safer, faster, cheaper and more efficient.
The modern business world is using a new buzzword: “Open innovation”. What does it mean? How “open” do we need to be? What could be the benefit? And what does it look like in reality?
Scientists from the Department of Biotechnology at the University of Natural Resources and Life Sciences (BOKU) Vienna and the Austrian Centre of Industrial Biotechnology (acib) discovered a gene switch in yeast, that was able to change twelve genes – and thereby the metabolic process of yeast as a whole. This work explains evolutionary events that happened more than 120 million years ago. The results have recently been published in the scientific journal Nature Communications and have the potential to be used in the food and feed industry and for the production of bio fuels and new building blocks for bioplastics.
Have you ever thought about how drugs are manufactured? They are often produced by microorganisms which secret them into their environment: a soup of media, the target drug and waste that must be eliminated. In the pharmaceutical industry, people use chromatography columns to purify the medication. This process is used for more than a century for the separation of compounds. One may think that everything should be already known for such a well-established process. Yet, acib researchers found out recently that already the connecting tubes and valves affect the quality of the separation process and – in the end – product quality.
More efficiency, more quality, more process safety, less costs, less waste – these are the target specifications of each and every production process in chemical industry. It seems quite ambitious to meet all these requirements, but a new key word has entered the engineering world: process intensification!
An interdisciplinary team of scientists is pioneering the development of synthetic glycobiology and trains 15 young researchers in the enabling technologies that underpin the development and exploitation of glycoscience: An exciting topic that promises to bring innovative solutions for the future!
Research funding is a highly competitive process and only a small fraction of applicants get the grant in the end. EU-Horizon 2020, with almost 80 billion Euros the largest research program worldwide, has an average success rate of only 14%. What is the secret of success of those, who have made it?
Antibiotic-resistant bacteria are not only restricted to clinical environments, nor do they always pose an immediate danger for humans. Various environmental niches are occupied by complex microbial communities that also include members that can carry one or different antibiotic resistances. The plant microbiome often harbors highly competitive microorganisms that can shield of pathogens and contribute to the host’s health. In their latest study researchers from acib-partner TU Graz have focused on antibiotic resistances in a common salad plant and found that the indigenous enterobacterial community contributes to the highly interesting profile.