It is still winter outside, and some may wish warmer temperatures to come soon. While humans sometimes need warmth to get going, cold-inducible promoters from Chinese Hamster Ovary (CHO) cells turned out to be interesting tools for the production of biopharmaceuticals at low temperatures.
Scientists from the Department of Biotechnology at the University of Natural Resources and Life Sciences (BOKU) Vienna and the Austrian Centre of Industrial Biotechnology (acib) discovered a gene switch in yeast, that was able to change twelve genes – and thereby the metabolic process of yeast as a whole. This work explains evolutionary events that happened more than 120 million years ago. The results have recently been published in the scientific journal Nature Communications and have the potential to be used in the food and feed industry and for the production of bio fuels and new building blocks for bioplastics.
The responsible transport gene that allows the production of lemon acid in large quantities was recently discovered. A breakthrough!
Membrane transport proteins play a key role in several metabolic pathways. They transport either actively or passively ions or biomolecules, such as metabolites, across the membranes. The construction of efficient cell factories, to produce valuable metabolites, requires a deeper understanding of transport capabilities. However, to understand these mechanisms, suitable protein production systems and membrane-like environments need to be developed in which full protein functionality is maintained.