This mini-review provides a comprehensive overview of the mating factor alpha (MFa) signal sequence from Saccharomyces cerevisiae, a cornerstone for recombinant protein secretion in yeast. The paper systematically explores the historical context and molecular mechanisms of MFa-guided protein transport via the post-translational secretory pathway.

Accurate and rapid quantification of immunoglobulin G (IgG) is critical in the manufacturing of plasma-derived therapeutics. This study addresses the limitations of traditional methods like nephelometry by validating a high-performance affinity chromatography method.

This study investigates the underlying genetic mechanisms, revealing a complex regulatory network distinct from the model yeast Saccharomyces cerevisiae. Transcriptional analysis identified six flocculin (FLO) genes as differentially expressed at low pH.

Improving efficiency of gene therapy: acib researchers and partners are tackling the complex challenge of purifying Adeno-Associated Virus (AAV) vectors, paving the way for more effective and accessible advanced medical treatments.

The escalating global plastic waste crisis demands innovative, environmentally friendly solutions. This research turns to an unexpected natural reservoir: carnivorous plants.

The biocatalytic synthesis of valuable chemicals offers a sustainable alternative to conventional chemical routes. This work focuses on improving a critical hydroxylation step in the synthesis of Tulipalin A, a small lactone with an exo-olefin group, that has significant potential as a polymer precursor.

First markerless mutagenesis system established, clarifying isoleucine biosynthesis and enabling synthetic pathway integration.

This study delves into the promising realm of NADH-driven enzymatic carboxylic acid reduction, a pivotal transformation in the field of industrial biotechnology.

Green chemistry in action: Our enzyme SpL enables the efficient production of important amide building blocks for drugs directly in water! Faster, cleaner, more sustainable – a breakthrough for industrial biotechnology.