plastic bottles

Plastic – the material of our time – is omnipresent. As the production is steadily increasing, its recycling lags behind. What if enzymes like esterases could make a change? While bringing about a sustainable life style will not get around reducing plastic usage, responsible resource management also necessitates the implementation of circular economy. As for that, the European Union established the Circular Economy Package. It made plastic one of the five priorities to be targeted and calls for novel and improved recycling processes. And, (bio)-chemical recycling using esterases might just be the method to boost our resource efficiency.

secretion in Pichia pastoris

Yeast cells are important workhorses for the “green” production of various chemicals and proteins. In many cases the biotechnological industry favours the secretive production of their target compounds, because of lower costs for purification and less complicated downstream processing. But the way from an intracellularly produced protein through the cellular secretion machinery to the outside of the cell is very long and hides numerous obstacles.  Researchers all over the world are looking for methods to overcome these hurdles  – so do acib researchers.

Microorganisms for energy – does it work? And how could this be connected with CO2 conversion? Microorganisms particularly gained interest in carbon capture and utilization research due to the ability to convert CO2 to a broad range of possible valuable products and fuels. Application of such microorganisms has become highly attractive as several different strains of pure as well as mixed cultures of microorganisms are suitable for application in biofuel and biochemical generation.

plasticwaste

Complex, recalcitrant polymers represent a barrier in the biodegradation process during anaerobic digestion (AD) towards biogas production. This concerns both, biopolymers from plant waste as well as synthetic polymeric plastics entering biogas plants as packaging material with food waste. Therefore, microbial populations and their enzymes involved in the hydrolysis of lignocellulose-rich plant material and modified polyesters are investigated to develop a strategy to biologically boost the conversion of waste to bioenergy by tailor-made microbial communities and bioaugmentation.

two reaching hands

Follow up with the second article of “Connection carbon”. Missed to read the first part? Here you go!

Among numerous carbon-carbon coupling reactions in organic synthesis, the Friedel-Crafts acylation enables the direct connection of aromatic compounds with carbonyl moieties. It is therefore one of the most popular chemical transformations and extensively used. The resulting products- aromatic ketones- are valuable building blocks and relevant to a range of industrial sectors, including the pharmaceutical, biotechnological and fine chemical industry. ACIB pioneers in developing a biocatalytic equivalent for this fundamental reaction, thereby exploiting a so-far little investigated cofactor-independent acyltransferase. But why considering enzymes to do this reaction?

In the past years the advent of microbiome research was facilitated by a tremendous decrease in DNA sequencing costs. The progression of sequencing technology and the growing demand for large datasets (beyond the size of the human genome) enabled this favorable progress, which even surpassed Moore’s Law. There are various technologies that benefited from these developments and many of them have a set position in modern laboratories.