Fungi are ubiquitous organisms which have made a beneficial contribution to human development. This association dates back to 3000 B.C. when it is believed that for the first time, Egyptians used yeast for baking bread and brewing beer. Later with the discovery of penicillin from Penicillium chrysogenum, fungal antibiotics gained widespread use in treatment of infections. In the research field too, fungi serve as a model for genetics and cell biology. Filamentous fungi are known for secreting huge amounts of secondary metabolites like enzymes, organic acids, cyclosporins, and steroids. These valuable compounds have vast applications in several industries such as food, beverages, textiles, and pharmaceuticals. A well-known filamentous fungi is Aspergillus niger, an industrial workhorse for production of high titers of organic acids and enzymes.