Enzyme spielen die erste Geige, die Zelle ist ein Saal für das gesamte – perfekt eingespielte – Orchester und ForscherInnen wirken als Komponisten? Heraus kommen dabei nicht etwa Töne sonder Düfte! Unser musikalischer Denkansatz veranschaulicht die komplexen Produktionsprozesse in der Biotechnologie anhand eines Beispiels aus dem Aromastoff-Bereich.
Enzymes are the tiny helpers of industrial biotechnology. Despite their microscopic size, they need to be tough and diligent because we want them to catalyze a broad range of reactions, ideally with the speed of light for ever after. In reality, however, many enzymes are like sensitive creatures, who need most careful attention and special treats to get their nicest behavior. Otherwise they might fade away like a tender flower in the blinking sun… and send the biotechnologists into terrible trouble. One strategy to find frugal enzymes is to look at thermophilic organisms. They sometimes harbor a treasure of more stable proteins because they are used to withstand somewhat unfriendly conditions such as high temperatures.
Some plants protect themselves with cyanide against voracious beetles, caterpillars or cattle, who want to nibble their delicious looking leaves. Everyone knows that cyanide is really toxic: In Agatha Christies murder stories the murderers take their victim’s breath with ‘sparkling cyanide’: a bit of innocent looking white powder potassium cyanide mixed into sparkling wine. Plants produce this poison with the help of enzymes when the plant is chewed.