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Technology Offers

 

In Silico identification of novel enzymes

The present invention uses bioinformatics methods to mine structural databases using three dimensional search templates termed “catalophores”. This technology can be applied to find enzymes catalyzing the same reaction, but without sequence similarities…..

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Project on Antibacterial Antibiotic Discovery and Development

Most of the antibiotics currently in medical use are produced by bacteria and fungi. UniVie has access to various unique collections of microbial isolates with high antibiotic production potential, and possesses wide experience in isolation and targeted screening of unique microbes. Together with acib, UniVie can offer a project on novel antibiotic discovery and development…

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Project on Antibacterial Antibiotic Discovery and Development

Bacterial secondary metabolites represent an incredibly rich source of potential drug candidates. However, most of the bacteria-derived natural products cannot be used due to suboptimal physicochemical or pharmacological properties. A novel approach provided by acib and the University of Vienna uses biosynthetic engineering and medicinal chemistry for the discovery and optimization of pharmaceutically active compounds.

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Predicting drug resistance mutations in receptor tyrosine kinases

Drug resistance mutations are the major limitation of kinase inhibitors in cancer
therapy. We are developing a novel in vitro method for predicting drug resistance
mutations in tumors, thereby allowing cost-efficient optimization of new inhibitors
and inhibitor combinations for reduced resistance potential.

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Platform BOSS: Biotechnological Optimizations by Selection Systems

Current screening systems are complex, time consuming and therefore expensive. acib has
developed a platform of selection strategies based on microbial survival. These new methods
enable easy, cost-efficient and very rapid screenings of billions of different mutations.

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Directed modification of proteins

Common immobilization techniques do not work for your enzyme? Your protein carries a post-translational modification that is difficult to introduce? You want to improve the oxidation stability of your protein? You want to increase the scope of your protein engineering?

=> Unnatural amino acids are the innovative solution!

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Combinatorial pathway assembly for green chemistry

You want to do “green” synthesis of your favorite compound? Your “green” synthesis needs fine-tuning? Commercial expression systems do not offer you enough flexibility to fine-tune?

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Synthesis of bio-based resveratrol analogues

A new reaction cascade converts inexpensive ferulic acid derivatives into highly valuable bio-based oxidants that are very promising constituents for lubricants,cosmetics/health products and polymer packaging.

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Porous Hydrophilic Nanomembranes

The present invention relates to the generation and use of self-standing giant porous hydrophilic nanomembranes (PHNM). Currently available nanomembranes are mainly hydrophobic, which greatly limits their application in biotechnology and life sciences. In contrast, the PHNM is made from hydrophilic polymers and is therefore ideally suited for use in aqueous media.

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New Hydroxynitrile Lyases

The present invention relates to novel hydroxynitrile lyase enzymes for the preparation of enantiopure cyanohydrins. For the application of HNL enzymes on scale, they should be I) easily available in high amounts, II) highly active, III) highly selective and IV) stable at process conditions.
The new HNL from the fern Davallia teyermannii fulfills all these criteria.

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Biocatalytic Friedel – Crafts Acylations

This technology provides a biocatalytic method for the regioselective monoacylation of phenols or aminophenols serving as acyl acceptors in the presence of acyl donor molecules of the formula R2-C(=O)-R3 and acyl transferase (ATase) enzymes as catalysts. The produced phenols can be used in different markets, such as cosmetics, aroma (natural), industrial enzymes (5 billion US$ p.a.), biocatalysis, pharmaceutical industry, agricultural chemistry, biological pesticides.

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acib impressions
hands with plate
Rot fluoreszierende Bakterien
24 bacteria
microorganisms on plate
Labs Wien 5
Dunkle Kulturen 1
Fermenter Monitoring
Labs Wien 1