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Scientific publications are important qualitative indicators of a research institution. They account for scientific excellence and serve as platform to present new results to the scientific community.The publication of innovative scientific knowhow is the basis for the development of new ideas and research strategies.

Publications in refereed journals 2014

F. Krainer, R. Pletzenauer, L. Rossetti, C. Herwig, A. Glieder, O. Spadiut: Purification and basic biochemical characterization of 19 recombinant plant peroxidase isoenzymes produced in Pichia pastoris, Protein Expression Purif., 2014, 95, 104-112

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M. Hajnsek, D. Schiffer, D. Harrich, D. Koller, V. Verient, A. Heinzle, B. Binder, E. Sigl, F. Sinner, G. Guebitz: An electrochemical sensor for early detection of wound infection based on myeloperoxidase activity, Sensors Actuators B: Chem., 2014, 209, 265-274; http://dx.doi,org/doi:10.1016/j.snb.2014.11.125

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R. Wiedner, B. Kothbauer, T. Pavkov-Keller, M. Gruber-Khadjawi, K. Gruber, H. Schwab, K. Steiner: Improving the properties of bacterial (R)-selective hydroxynitrile lyases for industrial application, ChemCatChem, 2014; http://dx.doi.org/10.1002/cctc.201402742

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K. Ortmayer, J. Nocon, B. Gasser, D. Mattanovich, S. Hann, G. Köllensperger: Sample preparation workflow for the liquid chromatography tandem mass spectrometry based analysis of nicotinamide adenine dinucleotide phosphate cofactors in yeast, J. Sep. Sci., 2014, 37(16), 2185-2191

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C. Fuchs, R. Simon, W. Riethorst, F. Zepeck, W. Kroutil: Synthesis of (R)- or (S)-Valinol Using w-Transaminases in Aqueous and Organic Media, Bioorg. Med. Chem., 2014, 22, 5558-5562

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J. Griss, T. Sachsenberg, M. Walzer, L. Gatto, J. Hartler, G. Thallinger, A. Jones, N. Bandeira, I. Xenarios, O. Kohlbacher, J. Vizcaíno , H. Hermjakob: The mzTab Data Exchange Format: communicating MS-based proteomics and metabolomics experimental results to a wider audience, Mol. Cell. Proteomics, 2014, 13, 2765-2775

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M. Monschein, C. Reisinger, B. Nidetzky: Dissecting the effect of chemical additives on the enzymatic hydrolysis of pretreated wheat straw, Bioresour. Technol., 2014, 169, 713-722

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S. Pan, A. Jungbauer, R. Hahn: Integrated Continuous Dissolution, Refolding and Tag Removal of Fusion Proteins from Inclusion Bodies in a Tubular Reactor, J. Biotechnol., 2014, 185,39-50

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S. Pan, M. Zelger, R. Hahn, A. Jungbauer: Continuous Protein Refolding in a Tubular Reactor, Chem. Eng. Sci., 2014, 116, 763-772

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C. Ruth, M. Buchetics, V. Vidimce, D. Kotz, S. Naschberger, D. Mattanovich, H. Pichler, B. Gasser: Pichia pastoris Aft1 – a novel transcription factor, enhancing recombinant protein secretion, Microb. Cell Fact., 2014, 13, 120

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A. Mellitzer, C. Ruth, C. Gustafsson, M. Welch, R. Birner-Grünberger, R. Weis, T. Purkarthofer, A. Glieder: Synergistic modular promoter and gene optimization to push cellulase secretion by Pichia pastoris beyond existing benchmarks, J. Biotechnol., 2014; http://dx.doi.org/10.1016/j.jbiotec.2014.08.035

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Z. Assaf, E. Eger, Z. Vitnik, W. Fabian, D. Ribitsch, G. Guebitz, K. Faber, M. Hall: Identification and Application of Enantiocomplementary Lactamases for Vince Lactam Derivatives, ChemCatChem, 2014, 6(9), 2517-2521

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K. Schmölzer, C. Luley-Goedl, T. Czabany, D. Ribitsch, H. Schwab, B. Nidetzky: Mechanistic study of CMP-Neu5Ac hydrolysis by alpha2,3-
sialyltransferase from Pasteurella dagmatis, FEBS Lett., 2014, 588 (17), 2978-2984

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A. Maccani, M. Hackl, C. Leitner, W. Steinfellner, A. Graf, N. Tatto, M. Karbiener, M. Scheideler, J. Grillari, D. Mattanovich, R. Kunert, N. Borth, R. Grabherr, W. Ernst: Identification of microRNAs specific for high producer CHO cell lines using steady-state cultivation, Appl. Microbiol. Biotechnol., 2014, 98, 7535-7548

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G. Guebitz, E. Herrero Acero: Biosilica-loaded poly(ε-caprolactone) nanofibers: A step closer to bioprinted materials with tunable properties, Biotechnol. J., 2014; http://dx.doi.org/10.1002/biot.201400383

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L. Quek, S. Dietmair, M. Hanscho, V. Martinez, N. Borth, L. Nielsen: Reducing Recon 2 for steady-state flux analysis of HEK cell culture, J. Biotechnol., 2014, 184, 172-178

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A. Emmerstorfer, T. Wriessnegger, M. Hirz, H. Pichler: Overexpression of membrane proteins from higher eukaryotes in yeast, Appl. Microbiol. Biotechnol., 2014; http://dx.doi.org/10.1007/s00253-014-5948-4

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R. Sommer, P. Satzer, A. Tscheliessnig, H. Schulz, B. Helk, A. Jungbauer: COMBINED POLYETHYLENE GLYCOL AND CACL2 PRECIPITATION FOR THE CAPTURE AND PURIFICATION OF RECOMBINANT ANTIBODIES, Process Biochem., 2014; http://dx.doi.org/10.1016/j.procbio.2014.07.012

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R. Wiedner, M. Gruber-Khadjawi, H. Schwab, K. Steiner: Discovery of a novel (R)-selective bacterial hydroxynitrile lyase from Acidobacterium capsulatum, CSBJ, 2014; http://dx.doi.org/10.1016/j.csbj.2014.07.002

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J. Schellenberg, T. Verbeke, P. McQueen, V. Spicer, O. Krokhin, X. Zhang, B. Fristensky, G. Thallinger, B. Henrissat, J. Wilkins, D. Levin, R. Sparling: Whole genome sequence enhancement and molecular gene expression profile of Clostridium stercorarium DSM8532T by RNA-seq transcriptomics and high-throughput proteomics, BMC GENOMICS, 2014, 15, 567

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C. Fuchs, M. Hollauf, M. Meissner, R. Simon, T. Besset, J. Reek, W. Riethorst, F. Zepeck, W. Kroutil: Dynamic Kinetic Resolution of 2-Phenyl Propanal Derivatives to Yield a-Chiral Primary Amines via Bioamination, Adv. Synth. Catal., 2014, 356 (10), 2257-2265

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K. Grillitsch, P. Tarazona, L. Klug, T. Wriessnegger, M. Spanova, G. Zellnig, E. Leitner, I. Feussner, G. Daum: Isolation and characterization of the plasma membrane from the yeast Pichia pastoris, BBA-MOL CELL BIOL L, 2014, 1838 (/), 1890-1897

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T. Wriessnegger, P. Augustin, M. Engleder, E. Leitner, M. Müller, G. Zellnig, H. Pichler: Production of the sesquiterpenoid (+)-nootkatone by metabolic engineering of Pichia pastoris, Metab. Eng., 2014, 24, 18-29

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J. Nocon, M. Steiger, M. Pfeffer, S. Sohn, T. Kim, M. Maurer, H. Rußmayer, C. Haberhauer-Troyer, S. Hann, G. Köllensperger, B. Gasser, . Sang Yup Lee, D. Mattanovich: Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production, Metab. Eng., 2014, 24, 129-138

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C. Walther, S. Mayer, A. Jungbauer, A. Dürauer: Getting ready for PAT: Scale up and inline monitoring of protein refolding of Npro fusion proteins, Process Biochem., 2014, Process Biochemistry 49 (2014), pp. 1113-1121
Process Biochemistry 49 (2014), pp. Process Biochemistry 49 (2014), pp. 1113-1121
1113-1121


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K. Napora-Wijata, G. Strohmeier, M. Winkler: Biocatalytic reduction of carboxylic acids, Biotechnol. J., 2014, 9, 822-843

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E. Herrero Acero, T. Kudanga, A. Ortner, I. Kaluzna, S. de Wildemann, G. Nyanhongo, G. Guebitz: Laccase functionalization of flax and coconut fibres, Polymers, 2014, 6(6), 1676-1684

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R. Nilsson, K. Hyde, J. Pawlowska, M. Ryberg, L. Tedersoo, A. Aas, S. Alias, A. Alves, C. Anderson, A. Antonelli, A. Arnold, B. Bahnmann, M. Bahram, J. Bengtsson-Palme, A. Berlin, S. Branco, P. Chomnunti, A. Dissanayake, R. Drenkhan, H. Friberg, T. Froslev, B. Halwachs, e. al.: Improving ITS sequence data for identification of plant pathogenic fungi, Fungal Divers., 2014; http://dx.doi.org/10.1007/s13225-014-0291-8

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N. Richter, R. Simon, W. Kroutil, J. Ward, H. Hailes: Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω- transaminase, Chem. Commun., 2014, 50, 6098

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C. Sayer, R. Martinez-Torres, N. Richter, M. Isupov, H. Hailes, J. Ward: The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca, FEBS J., 2014, 281(9), 2240-2253

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J. Hernandez-Bort, V. Shanmukam, M. Pabst, M. Windwarder, L. Neumann, A. Alchalabi, G. Krebiehl, G. Köllensperger, S. Hann, D. Sonntag, F. Altmann, C. Heel, N. Borth: Reduced quenching and extraction time in mammalian cells using filtration and syringe extraction, J. Biotechnol., 2014, 182-183, 97-103; http://dx.doi.org/10.1016/j.jbiotec.2014.04.014

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I. Bednar, E. Berger, N. Lendero Krajnc, J. Vidic, A. Podgornik, A. Jungbauer, R. Tscheliessnig: Surfaces Energies of Monoliths by Inverse Liquid Chromatography and Contact Angles, LANGMUIR, 2014, 30, 5435-5440

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L. Fliedl, G. Manhart, F. Kast, H. Katinger, R. Kunert, J. Grillari, M. Wieser, R. Grillari-Voglauer: Novel human Renal Proximal Tubular Cell Line for the Production of complex proteins, J. Biotechnol., 2014, 176, 29-39

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L. Fliedl, M. Wieser, G. Manhart, M. Gerstl, J. Grillari, R. Grillari-Voglauer: New Human Renal Proximal Tubular Epithelial Cell panel to reveal influence of GGT activity on nephrotoxicity, ALTEX-ALTERN ANIM EX, 2014; http://dx.doi.org/10.14573/altex1311152

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V. Jadhav, M. Hackl, G. Klanert, J. Hernandez-Bort, N. Borth, J. Grillari: Stable overexpression of miR-17 enhances recombinant protein production of CHO cells, J. Biotechnol., 2014, 175, 38-44

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O. Tomescu, D. Mattanovich, G. Thallinger: Integrative Analysis of -omics Data: A Method Comparison, BMC SYST BIOL, 2014, 8(Suppl 2), 54

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G. Klanert, V. Jadhav, K. Chanoumidou, J. Grillari, N. Borth, M. Hackl: Endogenous MicroRNA Clusters Outperform Chimeric Sequence Clusters in Chinese Hamster Ovary Cells, Biotechnol. J., 2014, 9(4), 538-544

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K. Napora-Wijata, K. Robins, A. Osoria-Lozada, M. Winkler: Whole cell carboxylate reduction for the synthesis of 3-hydroxytyrosol, ChemCatChem, 2014, 6(4), 1089-1095

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D. Rodrigues, M. Kittelmann, F. Eggimann, T. Bachler, S. Abad, S. Hanlon, A. Camattari, A. Glieder, B. Wirz, M. Winkler, S. Lütz: Production of recombinant human aldehyde oxidase in E. coli and optimization of its application for preparative synthesis of oxidized drug metabolites, ChemCatChem, 2014, 6, 1028-42

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T. Schmidberger, R. Gutmann, K. Bayer, J. Kronthaler, R. Huber: Advanced online monitoring of cell culture off-gas using proton transfer reaction mass spectrometry, Biotechnol. Prog., 2014, 30(2), 496-504

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B. Petschacher, N. Staunig, M. Müller, S. DeWildeman, K. Gruber, A. Glieder: Cofactor Specificity Engineering of S. mutans NADH Oxidase 2 for NAD(P)+ Regeneration in Biocatalytic Oxidations, CSBJ, 2014, 9,(14), e201402005

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D. Ruckerbauer, C. Jungreuthmayer, J. Zanghellini: Design of optimally constructed metabolic networks of minimal functionality, PloS ONE, 2014; http://dx.doi.org/10.1371/journal.pone.0092583

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L. Fliedl, M. Wieser, G. Manhart, M. Gerstl, A. Kahn, J. Grillari, R. Grillari-Voglauer: Controversial Role of Gamma-Glutamyl * Transferase Activity in Cisplatin Nephrotoxicity, Chem. Res. Toxicol., 2014; http://dx.doi.org/10.14573/altex1311152

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L. Näätsaari, F. Krainer, M. Schubert, A. Glieder, G. Thallinger: Peroxidase gene discovery from the horseradish transcriptome, BMC GENOMICS, 2014, 15, 227

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T. Vogl, C. Ruth, J. Pitzer, T. Kickenweiz, A. Glieder: Synthetic core promoters for Pichia pastoris, ACS Synth. Biol., 2014, 3(3), 188-91

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D. Mattanovich, M. Sauer, B. Gasser: Yeast biotechnology: teaching the old dog new tricks, Microb. Cell Fact., 2014, 13, 34

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E. Prasetyo, R. Diaz Rodriguez, B. Lukesch, S. Weiss, M. Murkovic, E. Katsoyannos, C. Sygmund, R. Ludwig, G. Nyanhongo, G. Gübitz: Laccase-cellobiose dehydrogenase catalyzed detoxification of phenolic rich olive processing residues, Int. J. Environ. Sci. Technol., 2014; http://dx.doi.org/10.1007/s13762-014-0526-y

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C. Wuensch, J. Gross, G. Steinkellner, A. Lyskowski, K. Gruber, S. Glueck, K. Faber: Regioselective ortho-Carboxylation of Phenols Catalyzed by Benzoic Acid Decarboxylases: a Biocatalytic Equivalent to the Kolbe-Schmitt Reaction, RSC Adv., 2014, 4, 9673-9679

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R. Simon, J. Sattler, J. Farnberger, C. Fuchs, N. Richter, F. Zepeck, W. Kroutil: Enzymatic Asymmetric Synthesis of the Silodosin Amine Intermediate, TETRAHEDRON-ASYMMETR, 2014, 25, 284-288

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A. El-Heliebi, T. Kroneis, K. Wagner, K. Meditz, D. Kolb, J. Feichtinger, G. Thallinger, F. Quehenberger, B. Liegl-Atzwanger, B. Rinner: esolving Tumor Heterogeneity: Genes Involved in Chordoma Cell Development Identified by Low-Template Analysis of Morphologically Distinct Cells, PloS ONE, 2014, 9, e87663

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M. Delic, R. Göngrich, D. Mattanovich, B. Gasser: Engineering of protein folding and secretion – strategies to overcome bottlenecks for efficient production of recombinant proteins, Antioxid. Redox Signal., 2014; http://dx.doi.org/10.1089/ars.2014.5844

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M. Gerstl, M. Joksch, G. Fafilek: Designing a Simple Electronic Tongue for Fermentation Monitoring, J. Anal. Bioanal. Tech., 2014, 2013, 12

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A. Lyskowski, C. Gruber, G. Steinkellner, M. Schürmann, H. Schwab, K. Gruber, K. Steiner: Crystal structure of an (R)-selective ω-transaminase from Aspergillus terreus, PloS ONE, 2014; http://dx.doi.org/10.1371/journal.pone.0087350

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M. Hackl, V. Jadhav, G. Klanert, J. Grillari, N. Borth: Dicer expression regulates the proliferation rate of Chinese hamster ovary cells, Biotechnol. Bioeng., 2014; http://dx.doi.org/10.1016/j.jbiotec.2013.12.018

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M. Hackl, V. Jadhav, G. Klanert, M. Karbiener, M. Scheideler, J. Grillari, N. Borth: Analysis of microRNA transcription and post-transcriptional processing by Dicer in the context of CHO cell proliferation, J. Biotechnol., 2014; http://dx.doi.org/10.1016/j.jbiotec.2013.12.018

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A. Engel, H. Sobek, M. Greif, S. Malik, M. Thomann, C. Jung, D. Reusch, D. Ribitsch, S. Zitzenbacher, C. Luley, K. Schmoelzer, T. Czabany, B. Nidetzky, H. Schwab, R. Mueller: Rec. ST6Gal-I variants to control enzymatic activity in processes of in vitro glycoengineering, MBC Proc, 2014, 7, 110

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O. Rupp, J. Becker, K. Brinkrolf, C. Timmermann, N. Borth, A. Pühler, T. Noll, A. Goesmann: Construction of a Public CHO Cell Line Transcript Database Using Versatile Bioinformatics Analysis Pipelines, PloS ONE, 2014, 9, e85568

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S. Kienesberger, H. Sprenger, S. Wolfgruber, B. Halwachs, G. Thallinger, G. Perez-Perez, M. Blaser, E. Zechner, G. Gorkiewicz: Comparative Genome Analysis of Campylobacter fetus Subspecies Revealed Horizontally Acquired Genetic Elements Important for Virulence and Niche Specificity, PloS ONE, 2014, 9, e85491

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K. Weinhandl, M. Winkler, A. Glieder, A. Camattari: Carbon source dependent promoters in yeasts, Microb. Cell Fact., 2014; http://dx.doi.org/doi:10.1186/1475-2859-13-5

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A. Maccani, N. Landes, G. Stadlmayr, D. Maresch, C. Leitner, M. Maurer, B. Gasser, W. Ernst, R. Kunert, D. Mattanovich: Pichia pastoris secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space-time yields for less complex proteins, Biotechnol. J., 2014; http://dx.doi.org/10.1002/biot.201300305

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C. Walther, S. Mayer, A. Trefilov, G. Sekot, R. Hahn, A. Jungbauer, A. Dürauer: Prediction of inclusion body solubilization from shaken to stirred reactors, Biotechnol. Bioeng., 2014, 111, 84-94

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R. Simon, E. Busto, N. Richter, F. Belaj, W. Kroutil: Chemoenzymatic Synthesis of Enantiomerically Pure syn-Configured 1-Aryl-3- methylisochroman Derivatives, Eur. J. Org. Chem., 2014, 2014, 111-121

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J. Tong, T. Cohnert, P. Regitnig, J. Kohlbacher, R. Birner-Grünberger, A. Schriefl, G. Sommer, G. Holzapfel: Variations of dissection properties and mass fractions with thrombus age in human abdominal aortic aneurysms, J. Biomech., 2014, 47, 14-23

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J. Sattler, M. Fuchs, F. Mutti, B. Grischek, P. Engel, J. Pfeffer, J. Woodley, W. Kroutil: Introducing an In Situ Capping Strategy in Systems Biocatalysis To Access 6-Aminohexanoic acid, Angew. Chem., 2014, 53, 14153-14157

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C. Kubicek, T. Starr, N. Glass: Plant cell wall degrading enzymes and their secretion in plant pathogenic fungi , Annu. Rev. Phytopathol., 2014, 52, 427-451

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I. Klymiuk, C. Högenauer, B. Halwachs, G. Thallinger, W. Fricke, C. Steininger: A physicians’ wish list for the clinical application of intestinal metagenomics, PLOS Med., 2014, 11(4), e1001627

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J. Schrittwieser, B. Groenendaal, V. Resch, D. Ghislieri, D. Ghislieri, S. Wallner, E. Fischereder, E. Fuchs, B. Grischek, J. Sattler, P. Macheroux, N. Turner, W. Kroutil: Deracemization By Simultaneous Bio-oxidative Kinetic Resolution and Stereoinversion, Angew. Chem., 2014; http://dx.doi.org/10.1002/anie.201400027

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C. Zachow, H. Müller, R. Tilcher, G. Berg: Differences between the rhizosphere microbiome of Beta vulgaris 2 ssp. maritima – ancestor of all beet crops – and modern sugar beets, Front. Microbiol., 2014, 5, Article 415

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G. Steinkellner, C. Gruber, T. Pavkov-Keller, A. Binter, K. Steiner, C. Winkler, A. Lyskowski, O. Schwamberger, M. Oberer, H. Schwab, K. Faber, P. Macheroux, K. Gruber: Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations, Nature Communications, 2014, 5,ArtNr.: 4150

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G. Berg, M. Grube, M. Schloter, K. Smalla: Unraveling the plant microbiome: looking back and future
perspectives, Front. Microbiol., 2014, 5, 148

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D. Chu, K. Klavins, G. Köllensperger, S. Hann: Speciation analysis of sugar phosphates via anion exchange chromatography combined with inductively coupled plasma dynamic reaction cell mass spectrometry-optimization for the analysis of yeast cell extracts, J. Anal. At. Spectrom., 2014, 29, 915-925

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J. Mairhofer, P. Krempl, G. Thallinger, G. Striedner: Finished Genome Sequence of Escherichia coli K-12 Strain HMS174 (ATCC 47011), Gen. Announce., 2014, 2 (6), e00975-14

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P. Krempl, J. Mairhofer, G. Striedner, G. Thallinger: Finished Genome Sequence of the Laboratory Strain Escherichia coli K-12 RV308 (ATCC 31608), Gen. Announce., 2014, 2, e00971-14

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