Glycosyl transferases (GT) are extremely efficient biocatalysts that can be used for the synthesis of special carbohydrates and glycoconjugates. Famous examples of such products include human milk oligosaccharides that serve as prebiotics and glycosides of flavonoids with improved stability and solubility. The new substances could serve as antibiotics or even for the treatment of cancer.
Unfortunately, the large-scale application of GT has been hampered by their low operational stability and by the high cost of their glycosyl donor. The EU-funded project “SuSy” aims to solve both problems by a combination of enzyme and process engineering. On the one hand, the production of stable biocatalysts will be facilitated by the development of a suitable expression system, the design of optimized variants and the development of immobilized formulations. On the other hand, the production and recycling of nucleotide-activated sugars will be accomplished by exploiting the reaction of sucrose synthase (SuSy).
The participants in this EU-funded, international project comprise three universities, the research institute acib and four SMEs.