Protein Design & Engineering

In nature, proteins evolve to support organisms’  survival and propagation. For utilization outside their original habitat proteins need to be re- or de novo designed and adapted to  non-natural conditions and application-specific requirements using  protein engineering.

Our team has broad expertise in the fields of molecular  enzymology, structural biology and biotechnology. Research activities increase the fundamental knowledge on structure-function relationships of proteins on the molecular level by investigating for example catalytic mechanisms, selectivity and specificity, stability or interactions with other (macro-)molecules.

We apply our expertise to reach new milestones like the design of minimal enzymes or complex enzyme systems. A major challenge is the design and engineering of unprecedented functionalities, which will enable industrial biocatalysis to perform chemical reactions not yet accessible by the current portfolio of biocatalysts.

 

Key Researcher

Prof. Dr. Helmut Schwab

Coordination/Contact

Dr. Sabine Feichtenhofer
m: sabine.feichtenhofer@acib.at